The Dragons quartet of Aaron Wainwright, Elliot Dee, Ross Moriarty and Hallam Amos all featured as Wales defeated Italy 26-15 on Saturday afternoon.
Tries from Josh Adams and Owen Watkin steered Wales to a record equalling 11th win in a row as they made it two out of two on the road in the 2019 Guinness Six Nations.
Warren Gatland made 10 changes to the side that beat the French in Paris in Round 1 and there were too many errors for Wales to push for a bonus-point win.
They led 12-10 at the break thanks to four penalties form Dan Biggar and then pushed on after the break.
Wales are next in action in Cardiff against England at the Principality Stadium on February 23.