Harry Mallinder comes into the Saints’ side at fullback, whilst there are three new faces in the forwards, tight head Jamal Ford-Robinson, Number 8 Mitch Eadie and former Cardiff Blues lock Michael Paterson all start.
Saints have six players away on international duty, whilst George North is out injured alongside seven other teammates.
Saints Team To Play Dragons: 15 Harry Mallinder, 14 Juan Pablo Estelles, 13 Rory Hutchinson, 12 Tom Stephenson, 11 Ken Pisi, 10 Stephen Myler, 9 Cobus Reinach, 1 Francois van Wyk, 2 Reece Marshall, 3 Jamal Ford-Robinson, 4 Michael Paterson, 5 Sam Dickinson (capt), 6 Tom Wood, 7 Ben Nutely, 8 Mitch Eadie
Replacements: Mikey Haywood, Matt Beesley, Paul Hill, Alex Moon, Teimana Harrison, Alex Mitchell, James Grayson, Ben Foden