Jenkins will captain the side for a fourth time and is included in a new-look front-row. Ospreys hooker Scott Baldwin makes his first start for his country and they will pack down alongside Samson Lee.
Experienced duo Bradley Davies and Luke Charteris come into the second-row whilst there is one change in the back-row with Justin Tipuric starting at openside flanker alongside Dan Lydiate and Taulupe Faletau.
Mike Phillips and Rhys Priestland form the half-back partnership and in the midfield Wales welcome back Scott Williams from injury who links up with Jamie Roberts.
The back-three consists of Liam Williams at full-back with George North and Alex Cuthbert on the wings.
"We have made a number of changes, but we are going out there with what we think is a strong side to take on Fiji,” said Gatland.
"The whole squad has been working very hard and were pushing for selection last week so it's an opportunity for them to start.
"We were pleased with the performance last week and we will be looking to build on that and get the result we want this weekend.
"We have made some changes, some have been enforced due to injury but we don't feel it weakens the side.”
On the bench, Scarlets pair Emyr Phillips and Rhodri Jones join uncapped former Wales U20 prop Nicky Smith as the front-row cover. Ospreys duo Alun Wyn Jones and James King complete the forward contingent. Rhodri Williams, James Hook and Cory Allen are named as backs cover.
WALES TEAM TO PLAY FIJI
Liam Williams (Scarlets), Alex Cuthbert (Cardiff Blues), Scott Williams (Scarlets), Jamie Roberts (Racing Metro), George North (Northampton Saints), Rhys Priestland (Scarlets), Mike Phillips (Racing Metro), Gethin Jenkins (Cardiff Blues, CAPT), Scott Baldwin (Ospreys), Samson Lee (Scarlets), Bradley Davies (Wasps), Luke Charteris (Racing Metro), Dan Lydiate (Unattached), Justin Tipuric (Ospreys), Taulupe Faletau (Newport Gwent Dragons).
Replacements: Emyr Phillips (Scarlets), Nicky Smith (Ospreys), Rhodri Jones (Scarlets), Alun Wyn Jones (Ospreys), James King (Ospreys), Rhodri Williams (Scarlets), James Hook (Gloucester), Cory Allen (Cardiff Blues).
