The regional side will take on Bayonne in the Amlin Challenge Cup; on Thursday 10th January KO 19:45 GMT.
Other changes include Hugh Gustafson, Adam Jones and Owen Evans who will start in the Dragons front five and the fresh look back line sees the inclusion of Steffan Jones, Will Harries and Mike Poole to take on the French side.
Dragons Team to face Bayonne
Tom Prydie, Will Harries, Adam Hughes, Andy Tuilagi, Mike Poole, Steffan Jones, Jonathan Evans, Owen Evans, Hugh Gustafson, Nathan Buck, Adam Jones, Rob Sidoli, Jevon Groves, Lewis Evans (c), Ieuan Jones.
Replacements:
Sam Parry, Nathan Williams, Tim Ryan, Andrew Coombs, Toby Faletau, Wayne Evans, Ashley Smith, Jack Dixon.
Bayonne Team to face the Dragons
Sam Gerber; Gabriele Lovobalavu, Thibault Lacroix, Lionel Mazars (c), Bastien Fuster; Jacques-Louis Potgieter, Guillaume Rouet; Pierre-Philippe Lafond, Anthony Etrillard, Renaud Boyoud, Rob Linde, Matt Graham, Abdellatif Boutaty, Jean Jo Marmouyet, Marc Baget-Rabarou.
Replacements:
David Roumieu, Neemia Tialata, Marc Legras, Dewald Senekal, Julien Puricelli, Mike Phillips, Manu Ahotaeiloa, Matthieu Ugalde.
